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Question

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For each reaction between a ketone and an amine, draw the curved arrow(s) to show the first step of the mechanism, then draw the final organic product. (If you accidentally changed the structures given in the problem, click on the red over/under arrows to remove any changes you have made.)

Answer “For each reaction between a ketone and an amine, draw the curved arrow(s) to show the first step of the mechanism, then draw the final organic product.”.

Concepts and reason

This problem is based upon the concept of a curved arrow representation for reaction of carbonyl compounds and amines.

Due to their high electrophilic nature, carbonyl compounds (aldehydes or ketones) can be highly reactive towards nucleophiles. Many nucleophilic addition reactions are required to make various organic compounds. Due to the presence of single pairs of electrons on Nitrogen, amines are extremely nucleophilic.

Fundamentals

Due to the presence of single pairs of electrons on Nitrogen, amines are highly nucleophilic. This is due to attacks on electrophiles such as carbonyl compounds and its electron density.

[Part 1]

Below is the reaction mechanism:

Below is the curved arrow symbol for chemical reaction and the product:

[Part 2]

Below is the reaction mechanism:

Below is the curved arrow symbol for chemical reaction and the product:

Answer

• Part 1: Below is the curved-arrow illustration of chemical reactions and the final product:

• Part 2: Below is the curved-arrow illustration of chemical reactions and the final product:

Last words

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