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Compare and contrast serine proteases and aspartic proteases. Not all answers will be used.
| Serine protease | Both | Aspartic protease |
- direct electrophilic attack by water
- covalent intermediate
- tetrahedral intermediate
- trigonal planar intermediate
- catalytic triad of serine, leucine, and valine
- four aspartic acids in active site
- catalytic triad of serine,histidine, and aspartic acid
- direct nucleophilic attack by water
- two aspartic acids in active site
♦ Relevant knowledgeProtease enzymes are a type of enzyme which has the catalytic role of hydrolysis of the peptide bond within proteins. Protease enzymes are found in the small intestine.
Serine protease
– The catalytic trio of serine and histamine.
– Covalent intermediate
Both:
– Water can directly nucleophilic attack
– Tetrahedal intermediate
Aspartic Protease
– 2 aspartic acid in active site
Except for the direct nucleophilic attack of water, the first two answers are correct.